We are investigating the cellular and molecular mechanisms by which microglia and other immune cells regulate central nervous system white matter health across the lifespan. We are identifying new roles for microglia in myelin development, homeostasis, and ageing.
We are identifying the roles of microglia and other immune cells in regulating myelin development or regeneration following injury, revealing therapeutic targets and strategies for conditions in which central nervous system white matter health is poor (e.g. perinatal brain injury/ cerebral palsy, multiple sclerosis, and normal ageing/ dementia). We actively collaborate with, and consult for, pharmaceutical industry to support drug development.
We use a comprehensive approach to our research, combining experimental modelling (in vitro, ex vivo, in vivo), transgenic and pharmacological manipulation, ‘omics (digital spatial profiling, RNA seq, sc-RNAseq, TRAPseq, proteomics), drug screening and nanoparticle delivery, and human neuropathological analysis and cell culture.
Georgie wins presentation prize. Georgie continues her winning streak, having won the best oral presentation by a senior trainee at…
Jonathan’s News & Views for Nature Neuroscience. Jonathan and Veronica wrote a News & Views for Nature Neuroscience, on a…
Lab conference presentations. Bianca gave her first oral presentation at the Unity Health Toronto Inflammation Symposium, Bianca and Jonathan presented…
Veronica visits Winnipeg. Veronica was invited by Soheila Karimi to give a seminar at the University of Manitoba in Winnipeg,…
Jonathan wins poster prize. Jonathan won best poster at the ACTRIMS Young Scientist Summit in Arizona, presenting his work on…
PhD student fellowship success. Jonathan was awarded the Vanier Canada Graduate Scholarship, and Bianca was awarded the Lloyd Carr-Harris PhD…
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