Harnessing the regenerative properties of inflammation for myelin health across the lifespan.


Fundamental Research

We are investigating the cellular and molecular mechanisms by which microglia and other immune cells regulate central nervous system white matter health across the lifespan. We are identifying new roles for microglia in myelin development, homeostasis, and ageing.

Translational Research

We are identifying the roles of microglia and other immune cells in regulating myelin development or regeneration following injury, revealing therapeutic targets and strategies for conditions in which central nervous system white matter health is poor (e.g. perinatal brain injury/ cerebral palsy, multiple sclerosis, and normal ageing/ dementia). We actively collaborate with, and consult for, pharmaceutical industry to support drug development.

Approaches & Innovation

We use a comprehensive approach to our research, combining experimental modelling (in vitro, ex vivo, in vivo), transgenic and pharmacological manipulation, ‘omics (digital spatial profiling, RNA seq, sc-RNAseq, TRAPseq, proteomics), drug screening and nanoparticle delivery, and human neuropathological analysis and cell culture.

Recent news
Niamh passes PhD viva

Niamh passes PhD viva. Congratulations to Niamh who has passed her PhD viva with no corrections. Thanks to David Lyons…

Come and work with us in the @UKDRI at Edinburgh! I'm looking for a postdoc with experience of in vivo calcium imaging to help us figure out mechanisms of synapse ingestion by glia and potential therapeutic targets for dementia. We're a nice team!


Very proud of @Sarah_A_Kent for winning the poster prize in the degeneration and neuropathology category at #EdNeuroDay !!! Congratulations Sarah, superstar!

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