We are investigating the cellular and molecular mechanisms by which microglia and other immune cells regulate central nervous system white matter health across the lifespan. We are identifying new roles for microglia in myelin development, homeostasis, and ageing.
We are identifying the roles of microglia and other immune cells in regulating myelin development or regeneration following injury, revealing therapeutic targets and strategies for conditions in which central nervous system white matter health is poor (e.g. perinatal brain injury/ cerebral palsy, multiple sclerosis, and normal ageing/ dementia). We actively collaborate with, and consult for, pharmaceutical industry to support drug development.
We use a comprehensive approach to our research, combining experimental modelling (in vitro, ex vivo, in vivo), transgenic and pharmacological manipulation, ‘omics (digital spatial profiling, RNA seq, sc-RNAseq, TRAPseq, proteomics), drug screening and nanoparticle delivery, and human neuropathological analysis and cell culture.
NEW PAPER ON SARS-COV2 IN FETAL BRAIN. Rebecca and Veronica have contributed to an important new study from the Long…
Niamh’s first author paper published on microglia regulation of myelin maintenance. Niamh’s paper discovering the role of microglia in maintenance…
Niamh passes PhD viva. Congratulations to Niamh who has passed her PhD viva with no corrections. Thanks to David Lyons…
Georgie wins UK DRI presentation prize. Congratulations to Georgie for winning a prize for her oral presentation at the UK…
Irene’s perspective article on chronic oligodendrocyte injury. Irene and Veronica published a perspective on chronic oligodendrocyte injury in neurological disorders…
Ayisha wins poster prize. The lab presented their work at the UK DRI Connectome meeting, where Ayisha won an honourable…
SUPPORTED BY











