We are investigating the cellular and molecular mechanisms by which microglia and other immune cells regulate central nervous system white matter health across the lifespan. We are identifying new roles for microglia in myelin development, homeostasis, and ageing.
We are identifying the roles of microglia and other immune cells in regulating myelin development or regeneration following injury, revealing therapeutic targets and strategies for conditions in which central nervous system white matter health is poor (e.g. perinatal brain injury/ cerebral palsy, multiple sclerosis, and normal ageing/ dementia). We actively collaborate with, and consult for, pharmaceutical industry to support drug development.
We use a comprehensive approach to our research, combining experimental modelling (in vitro, ex vivo, in vivo), transgenic and pharmacological manipulation, ‘omics (digital spatial profiling, RNA seq, sc-RNAseq, TRAPseq, proteomics), drug screening and nanoparticle delivery, and human neuropathological analysis and cell culture.
Lab conference presentations. Lucy presented at the ISN meeting in Portugal, Veronica presented at ISNI in Quebec City, and Lucy,…
New review article on microglia & myelin. We are pleased to present our new review article in Nature Reviews Immunology…
New publication on remyelination! We are pleased to present our new paper uncovering the critical role of astrocytes in remyelination…
Ayisha successfully defends her thesis. Congratulations to Ayisha for defending a fantastic PhD thesis and becoming Dr. Mahmood! Big thanks…
New lab members! The lab welcomes a new postdoc to the Edinburgh Team, Christina (Tina) Brown who is investigating white…
Lab conference presentations. Veronica & Alana discussed macrophage roles in myelin health at the NSAS Neurodegeneration & Resilience meeting, Alana…
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