Harnessing the regenerative properties of inflammation for myelin health across the lifespan.


Fundamental Research

We are investigating the cellular and molecular mechanisms by which microglia and other immune cells regulate central nervous system white matter health across the lifespan. We are identifying new roles for microglia in myelin development, homeostasis, and ageing.

Translational Research

We are identifying the roles of microglia and other immune cells in regulating myelin development or regeneration following injury, revealing therapeutic targets and strategies for conditions in which central nervous system white matter health is poor (e.g. perinatal brain injury/ cerebral palsy, multiple sclerosis, and normal ageing/ dementia). We actively collaborate with, and consult for, pharmaceutical industry to support drug development.

Approaches & Innovation

We use a comprehensive approach to our research, combining experimental modelling (in vitro, ex vivo, in vivo), transgenic and pharmacological manipulation, ‘omics (digital spatial profiling, RNA seq, sc-RNAseq, TRAPseq, proteomics), drug screening and nanoparticle delivery, and human neuropathological analysis and cell culture.

Recent news
New lab members!

New lab members! The lab welcomes a new postdoc to the Edinburgh Team, Christina (Tina) Brown who is investigating white…

Lab conference presentations.

Lab conference presentations. Veronica & Alana discussed macrophage roles in myelin health at the NSAS Neurodegeneration & Resilience meeting, Alana…

Another update - our #PaxLC trial is now open to even more states! If you are suffering from #LongCOVID and live in these states, please join our Paxlovid RCT by signing up here. Our trial requires no travel on your part. @kindred_health


For #PostdocAppreciationWeek we are grateful to our amazing postdocs Alana Hoffman, Georgie Craig, Ayisha Mahmood and Tina Brown who support our students while brilliantly leading their own projects


We are happy to launch the MicrogliaAtlas interactive website, including Microglia Aging Atlas (Aged from 3 MO to 24 MO for both sexes), Repopulation Atlas, and Replacement Atlas. Please feel free to use this tool to search data of microglia.

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