Original Articles

Reflective imaging of myelin integrity in the human and mouse central nervous systems. Front Cell Neurosci. Craig GA, Ryan L, Thapar J, McNamara NB, Hoffmann A, Page D, Rose J, Cox SR, Miron VE (2024). doi: 10.3389/fncel.2024.1408182.

Astrocyte-Oligodendrocyte interaction regulates central nervous system regeneration. Nature Communications. Molina-Gonzalez I, Holloway RK, Jiwaji Z, Dando O, Kent SA, Emelianova K, Lloyd AF, Forbes LH, Mahmood A, Skripuletz T, Gudi V, Febery JA, Johnson JA, Fowler JH, Kuhlmann T, Williams A, Chandran S, Stangel M, Howden AJM, Hardingham GE, Miron VE (2023). doi: 10.1038/s41467-023-39046-8.

Localized microglia dysregulation impairs central nervous system myelination in development. Acta Neuropathologica Communications. Holloway RK, Zhang L, Molina-Gonzalez I, Ton K, Nicoll JAR, Boardman JP, Liang Y, Williams A, Miron VE (2023). doi: 10.1186/s40478-023-01543-8.

Human astrocytes and microglia ingest more synapses in Alzheimer’s disease than in controls in a manner that can be reduced with antibody treatment. Cell Reports Medicine. Tzorias M, Daniels MJD, Davies C, King D, Baxter P, McKay S, Varga B, Popovic K, Stevenson AJ, Barrington J, Drinkwater E, Borella J, Holloway RK, Tulloch J, Latta C, Kandasamy J, Sokol D, Smith C, Miron VE, Karadottir RT, Hardingham G, Henstridge CM, Brennan PM, McColl BW, Spires-Jones TL (2023). doi: 10.1016/j.xcrm.2023.101175.

Immuno-epigenetic signature derived in saliva associates with postnatal inflammatory diseases and brain dysmaturation in preterm infants. Brain, Behaviour, and Immunity. Conole EL, Vaher K, Blesa M, Sullivan G, Stevenson AJ, Quigley AJ, Hall J, Thrippleton M, Murphy L, Basin M, Miron VE, Whalley HC, Marioni RE, Boardman JP, Cox SR (2023). doi: 10.1016/j.bbi.2023.03.011.

Haemorrhage of human foetal cortex associated with SARS-CoV-2 infection. Brain. Massimo M, Barelli C, Moreno C, Collesi C, Holloway RK, Crespo B, Zentilin L, Williams A, Miron VE, Giacca M, Long KR (2023). doi: 10.1093/brain/awac372.

Microglia regulate central nervous system myelin growth and integrity. Nature. McNamara NB, Munro DAD, Bestard-Cuche N, Uyeda A, Bogie JAFJ, Hoffmann A, Holloway RK, Molina-Gonzalez I, Askew KE, Mitchell S, Mungall W, Dodds M, Dittmayer C, Moss J, Rose J, Szymkowiak S, Amann L, McColl BW, Prinz M, Spires-Jones TL, Stenzel W, Horsburgh K, Hendriks JJA, Pridans C, Muramatsu R, Williams A, Priller J, Miron VE (2022). doi: 10.1038/s41586-022-05534-y.

Early-life inflammatory markers and subsequent psychotic and depressive episodes between 10 to 28 years of age. Brain, Behaviour, & Immunity- Health. Edmonson-Stait AJ, Shen X, Adams MJ, Barbu MC, Jones HJ, Miron VE, Allardyce J, Boardman JP, Lawrie SM, McIntosh AM, Khandaker GM, Kwong ASF, Whalley HC (2022). doi: 10.1016/j.bbih.2022.100528

The antimicrobial peptide cathlecidin drives development of Experimental Autoimmune Encephalomyelitis in mice by affecting Th17 differentiation. PloS Biology. Smith KJ, Minns D, McHugh B, Holloway RK, O’Connor R, Williams A, Melrose L, McPherson R, Anderton S, Miron VE, Davidson DJ, Gwyer-Findlay E (2022). PloS Biology. doi:10.1371/journal.pbio.3001554

DNA Methylation and Protein Markers of Chronic Inflammation and Their Associations With Brain and Cognitive Aging. Neurology.
Conole ELS, Stevenson AJ, Munoz Maniega S, Harris SE, Green C, Valdes Hernandez M, Harris MA, Bastin ME, Wardlaw JM, Deary IJ, Miron VE, Whalley HC, Marioni RE, Cox S (2021). DNA Methylation and Protein Markers of Chronic Inflammation and Their Associations With Brain and Cognitive Aging. Neurology. doi: 10.1212/WNL.0000000000012997

Impact of anti-PDGFRα antibody surface functionalization on LNC uptake by oligodendrocyte progenitor cells. International Journal of Pharmaceutics.
Labrak Y, Hertault B, Frisch B, Saulnier P, Lepeltier E, Miron VE, Muccioli GG, des Rieux A (2022). Impact of anti-PDGFRα antibody surface functionalization on LNC uptake by oligodendrocyte progenitor cells. International Journal of Pharmaceutics doi:10.1016/j.ijpharm.2022.121623

Microglial inflammasome activation drives developmental white matter injury. GLIA.
Holloway R, Ireland G, Sullivan G, Becher JC, Smith C, Boardman JP, Gressens P, Miron VE (2021). Microglial inflammasome activation drives developmental white matter injury. GLIA. doi: 10.1002/glia.23963

Central nervous system regeneration requires microglia death and repopulation. Nature Neuroscience.
Lloyd A, Davies C, Holloway R, Labrak Y, Ireland G, Carradori D, Dillenburg A, Borger E, Soong D, Richardson J, Kuhlmann T, Williams A, Pollard J, des Rieux A, Priller J, Miron VE (2019). Central nervous system regeneration requires microglia death and repopulation. Nature Neuroscience. doi: 10.1038/s41593-019-0418-z

Deletion of CSF1R enhancer selectively impacts CSF1R expression and development of tissue macrophage populations. Nature Communications.
Rojo R, Raper A, Ozdemir DO, Lefevre L, Grabert K, Wollscheid-Lengeling E, BradfordB, Caruso M, Gazova I, Sánchez A, Lisowski ZM, Alves J, Molina I, Davtyan H, Lodge RJ, Glover JD, Wallace R, Munro DAD, David E, Amit I, Miron VE, Priller J, Jenkins SJ, Hardingham G, Blurton-Jones M, Mabbott NA, Summers KM, Hohenstein P, Hume DA, Pridans C (2019). Deletion of CSF1R enhancer selectively impacts CSF1R expression and development of tissue macrophage populations. Nature Communications.

Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain. Brain.
Van Steenwinckel J, Schang AL, Krishnan ML, Degos V, Delahaye-Duriez A, Bokobza C, Csaba Z, Verdonk F, Montané A, Sigaut S, Hennebert O, Lebon S, Schwendimann L, Le Charpentier T, Hassan-Abdi R, Ball G, Aljabar P, Saxena A, Holloway RK, Birchmeier W, Baud O, Rowitch D, Miron VE, Chretien F, Leconte C, Besson VC, Petretto EG, Edwards AD, Hagberg H, Soussi-Yanicostas N, Fleiss B, Gressens P (2019) Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain. Brain.

Retinoic acid-loaded NFL-lipid nanocapsules promote oligodendrogenesis in focal white matter lesion. Biomaterials.
Carradori D, Labrak Y, Miron VE, Saulnier P, Eyer J, Préat V, des Rieux A (2019) Retinoic acid-loaded NFL-lipid nanocapsules promote oligodendrogenesis in focal white matter lesion. Biomaterials.

Activin receptors regulate the oligodendrocyte lineage in health and disease. Acta Neuropathologica.
Dillenburg A, Ireland GI, Holloway RK, Davies CL, Evans FL, Swire M, Bechler ME, Soong D, Yuen TJ, Su GH, Becher JC, Smith C, Williams A, Miron VE (2018). Activin receptors regulate the oligodendrocyte lineage in health and disease. Acta Neuropathologica.

The cerebrospinal fluid inflammatory response to preterm birth. Frontiers in Physiology.
Boardman JP, Ireland GI, Sullivan G, Pataky R, Fleiss B, Gressens P, Miron VE (2018) The cerebrospinal fluid inflammatory response to preterm birth. Frontiers in Physiology.

Stem cells from human apical papilla decrease neuro-inflammation and stimulate oligodendrocyte progenitor differentiation via activin-A secretion. Cellular and Molecular Life Sciences.
De Berdt P, Bottemanne P, Bianco J, Alhouayek M, Diogenes A, Lloyd A, Gerardo-Nava J, Brook GA, Miron VE, Muccioli GG, des Rieux A (2018). Stem cells from human apical papilla decrease neuro-inflammation and stimulate oligodendrocyte progenitor differentiation via activin-A secretion. Cellular and Molecular Life Sciences.

M2 microglia/ macrophages drive oligodendrocyte differentiation during CNS remyelination. Nature Neuroscience.
Miron VE, Boyd A, Zhao JW, Yuen TJ, Ruckh JM, Shadrach JL, vWijngaarden AJ, Wajers AJ, Williams A, Franklin RJM, ffrench-Constant C (2013). M2 microglia/ macrophages drive oligodendrocyte differentiation during CNS remyelination. Nature Neuroscience. 16(9):1211-1218.

Oligodendrocyte progenitor cell susceptibility to injury in Multiple Sclerosis. American Journal of Pathology.
Cui QL, Kuhlmann T, Miron VE, Leong SY, Fang J, Kennedy TE, Almazan G, Antel JP (2013) Oligodendrocyte progenitor cell susceptibility to injury in Multiple Sclerosis. Am. J. Pathol.,183: 516-525.

Identification of endothelin-2 as an inflammatory factor that promotes CNS remyelination. Brain.
Yuen TJ, Johnson KR, Miron VE, Zhao C, Quandt J, McFarland HF, Franklin RJM, ffrench-Constant C (2013) Identification of endothelin-2 as an inflammatory factor that promotes CNS remyelination. Brain. 136, 1035-1047.

Unconjugated bilirubin restricts oligodendrocyte differentiation and axonal myelination. Molecular Neurobiology.
Barateiro A, Miron VE, Santos S, Relvas J, Fernandes A, ffrench-Constant C, Brites D (2013) Unconjugated bilirubin restricts oligodendrocyte differentiation and axonal myelination. Molecular Neurobiology. 47, 632-644.

Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model. FASEB J.
Kim HJ, Miron VE, Dukala D, Proia RL, Ludwin SK, Traka M, Antel JP, Soliven B (2011) Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model. FASEB J. 25, 1509-1518.

Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices. American Journal of Pathology.
Miron VE, Ludwin SK, Darlington PJ, Jarjour AA, Soliven B, Kennedy TE, Antel JP (2010) Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices. Am. J. Pathol. 176, 2682-2694.

Response of human oligodendrocyte progenitors to growth factors and axon signals. J. Neuropathol. Exp. Neurol.
Cui QL, Fragoso G, Miron VE, Darlington PJ, Mushynski WE, Antel J, Almazan G (2010) Response of human oligodendrocyte progenitors to growth factors and axon signals. J. Neuropathol. Exp. Neurol. 69, 930-944.

Statin therapy inhibits remyelination in the central nervous system. American Journal of Pathology.
Miron VE, Zehntner SP, Kuhlmann T, Ludwin SK, Owens T, Kennedy TE, Bedell BJ, Antel JP (2009) Statin therapy inhibits remyelination in the central nervous system. Am. J. Pathol. 174, 1880-1890.

FTY720 modulates human oligodendrocyte progenitor process extension and survival. Ann. Neurology.
Miron VE, Jung CG, Kim HJ, Kennedy TE, Soliven B, Antel JP (2008) FTY720 modulates human oligodendrocyte progenitor process extension and survival. Ann. Neurol. 63, 61-71.

Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod. American Journal of Pathology.
Miron VE, Hall JA, Kennedy TE, Soliven B, Antel JP (2008) Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod. Am. J. Pathol. 173, 1143-1152.

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain.
Kuhlmann T, Miron VE, Cui Q, Wegner C, Antel J, Brück W (2008) Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain. 131, 1749-1758.

Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells. Glia.
Jung CG, Kim HJ, Miron VE, Cook S, Kennedy TE, Foster CA, Antel JP, Soliven B (2007) Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells. Glia. 55, 1656-1667.

Simvastatin regulates oligodendroglial process dynamics and survival. Glia.
Miron VE, Rajasekharan S, Jarjour AA, Zamvil SS, Kennedy TE, Antel JP (2007) Simvastatin regulates oligodendroglial process dynamics and survival. Glia. 55, 130-143).

Review Articles

CNS macrophage contributions to myelin health. Immunological Reviews.
Hoffmann A and Miron VE (2024). Immunological Reviews. doi: 10.1111/imr.13416

Disease modifying therapies for Parkinson disease: lessons from multiple sclerosis. Nature Reviews Immunology.
Kalia LV…Miron VE…Oh J (2024). Nature Reviews Neurology. doi: 10.1038/s41582-024-01023-0

Microglia in Health and Diseases: Integrative hubs of the central nervous system (CNS). Cold Spring Harbor Laboratory Press.
Sierra A, Miron VE, Paolicelli R, Ransohoff R (2024). Cold Spring Harbor Laboratory Press. doi: 10.1101/cshperspect.a041366

Key roles of glial cells in the encephalopathy of prematurity. GLIA.
Van Steenwinckel J, Bokobza C, Laforge M, Shearer IK, Miron VE, Rua R, Matta SM, Hill-Yardin EL, Fleiss B, Gressens P (2024). GLIA. doi: 10.1002/glia.24474

Microglia regulation of central nervous system myelin health and regeneration. Nature Reviews Immunology.
Kent S and Miron VE (2023). Nature Reviews Immunology. doi: 10.1038/s41577-023-00907-4

Chronic oligodendrocyte injury in central nervous system pathologies. Communications Biology.
Molina-Gonzalez I, Miron VE, Antel JP (2022). Communications Biology. doi: 10.1038/s42003-022-04248-1

Microglia states and nomenclature: a field at its crossroads. Neuron.
Paolicelli et al (2022). Microglia states and nomenclature: a field at its crossroads (2022). Neuron. doi: 10.1016/j.neuron.2022.10.020

Microglia as therapeutic targets for central nervous system remyelination. Current Opinion in Pharmacology.
Mahmood A and Miron VE. Microglia as therapeutic targets for central nervous system remyelination (2022). Current Opinion in Pharmacology, editors Tara DeSilva and Jeff Huang. doi: 10.1016/j.coph.2022.102188

White matter microglia heterogeneity in the CNS.
Acta Neuropathologica.
Amor S, McNamara NB, Gerrits E, Marzin MC, Kooistra SM, Miron VE, Nutma E. White matter microglia heterogeneity in the CNS (2022). Acta Neuropathologica. doi: 10.1007/s00401-021-02389-x

Replenishing our mind orchards: enhancing myelin renewal to rescue cognition in Alzheimer’s Disease. Neuron.
McNamara NB and Miron VE. Replenishing our mind orchards: enhancing myelin renewal to rescue cognition in Alzheimer’s Disease (2021). Neuron. doi: 10.1016/j.neuron.2021.06.024

Monocytes in central nervous system remyelination. Glia.
Forbes LH and Miron VE. Monocytes in central nervous system remyelination (2021). Glia. doi: 10.1002/glia.24111

Research Priorities for neuroimmunology: identifying the key research questions to be addressed by 2030. Wellcome Open Research.
MacKenzie G, Subramaniam S, Caldwell LJ, Fitzgerald D, Harrison NA, Hong S, Irani SR, Khandaker GM, Liston A, Miron VE, Mondelli V, Morgan BP, Pariante C, Shah DK, Taams LS, Teeling JL, Upthegrove R. Research Priorities for neuroimmunology: identifying the key research questions to be addressed by 2030 (2021). Wellcome Open Research.

Investigating microglia in health and disease: challenges and opportunities. Trends in Immunology.
Miron VE and Priller J. Investigating microglia in health and disease: challenges and opportunities (2020). Trends in Immunology.

The regenerative role of microglia in the central nervous system.
Nature Reviews Neurology.
Lloyd AF, Miron VE. The regenerative role of microglia in the central nervous system (2019). Nature Reviews Neurology.

Isolation and preparation of cells from focal remyelinating central nervous system lesions for RNA sequencing. Methods in Molecular Biology.
Davies CL, Gyoneva S, Coulter A, Ransohoff R, Miron VE. Cell isolation and RNA preparation from experimental focal remyelinating lesions (2019). Methods in Molecular Biology; editor David Lyons and Linde Kegel.

Astrocytes in myelination and remyelination. Neurosci Lett.
Molina-Gonzalez I and Miron VE. Astrocytes in myelination and remyelination (2019). Neurosci Lett, editors Holly Colognato and Akiko Nishiyama.

Microglia in developing white matter and perinatal brain injury. Neurosci Lett.
McNamara N and Miron VE. Microglia in developing white matter and perinatal brain injury (2019). Neurosci Lett, editors Marie-Eve Tremblay and Kaushik Sharma. doi: 10.1016/j.neulet.2019.134539

Microglia: origins, homeostasis, and roles in repair. Current Opinion in Neurobiology.
Lloyd AF, Davies CL, Miron VE. Microglia: origins, homeostasis, and roles in repair (2017). Current Opinion on Neurobiology, editors Beth Stevens and Alison Lloyd. 47:113-120.

Beyond immunomodulation: The regenerative role for regulatory T cells in central nervous system remyelination. Journal of Cell Comm Signal.
Miron VE. Beyond immunomodulation: The regenerative role for regulatory T cells in central nervous system remyelination (2017). Journal of Cell Comm Signal, commentary on Nature Neuroscience article.11:191-1

Microglia-driven regulation of oligodendroglial lineage cells, myelination, and remyelination. Journal of Leukocyte Biology.
Miron VE. Microglia-driven regulation of oligodendroglial lineage cells, myelination, and remyelination (2017). Journal of Leukocyte Biology.101: 1103-1108.

Distinct origins, gene expression and function of microglia and monocyte-derived macrophages in CNS myelin injury and regeneration. Clinical Immunology.
Davies CL, Miron VE. Distinct origins, gene expression and function of microglia and monocyte-derived macrophages in CNS myelin injury and regeneration (2016). Clinical Immunology. S1521-6616(16) 30142-30145.

Cellular and molecular mechanisms underpinning macrophage activation during remyelination. Frontiers in Cell and Developmental Biology.
Lloyd AF, Miron VE. Cellular and molecular mechanisms underpinning macrophage activation during remyelination (2016) Frontiers in Cell and Developmental Biology (Molecular Medicine). Review for Special topic: Revisiting neuroinflammation in myelin damage and repair: new molecular and cellular players. Jun 21;4:60.

Dissecting the damaging versus regenerative roles of CNS macrophages: implications for the use of immunomodulatory therapeutics. Regenerative Medicine.
Miron VE. Dissecting the damaging versus regenerative roles of CNS macrophages: implications for the use of immunomodulatory therapeutics (2014). Reg Med. Editorial, 8(6), 673-676.

Macrophages and CNS Remyelination. Journal of Neurochem. Review.
Miron VE, Franklin RJM. Macrophages and CNS Remyelination (2014). J. Neurochem. Review, 130(2):165-71.

Assessment of sphingosine-1-phosphate receptor expression and associated intracellular signalling cascades in primary cells of the human central nervous system. Methods in Molecular Biology.
Miron VE, Durafourt BA, Antel JP, Kennedy TE. Assessment of sphingosine-1-phosphate receptor expression and associated intracellular signalling cascades in primary cells of the human central nervous system (2012). Methods Mol Biol. 874, 141-154.

Effects of Current Medical Therapies on Reparative and Neuroprotective Functions in Multiple Sclerosis. Myelin Repair and Neuroprotection in Multiple Sclerosis.
Antel JP, Miron VE. Effects of Current Medical Therapies on Reparative and Neuroprotective Functions in Multiple Sclerosis (2012). Book chapter in “Myelin Repair and Neuroprotection in Multiple Sclerosis, Editors Ian Duncan & Robin Franklin.

The neurobiology of sphingosine-1-phosphate signalling and sphingosine-1-phosphate receptor modulators. Neurology.
Soliven B, Miron VE, Chun J. The neurobiology of sphingosine-1-phosphate signalling and sphingosine-1-phosphate receptor modulators (2011). Neurology. Feb 22; 76(8 Suppl 3), S9-14.

Cells of the oligodendroglial lineage, myelination, and remyelination. Biochim Biophys Acta.
Miron VE, Kuhlmann T, Antel JP. Cells of the oligodendroglial lineage, myelination, and remyelination (2011). Biochim Biophys Acta. Feb; 1812(2):184-93.

Isolation and Culture of Primary Human CNS Neural Cells. Protocols for Neural Cell Culture.
Blain M, Miron VE, et al. Isolation and Culture of Primary Human CNS Neural Cells (2009). Book chapter in “Protocols for Neural Cell Culture”, 4th edition, Editor Laurie Doering, 87-104.

Central nervous system-directed effects of FTY720 (fingolimod). J. Neurol. Sci.
Miron VE, Schubart A, Antel JP. Central nervous system-directed effects of FTY720 (fingolimod) (2008). J. Neurol. Sci. 274, 13-17.

Central nervous system effects of current and emerging multiple sclerosis-directed immuno-therapies. Clin. Neurol. Neurosurg.
Antel JP, Miron VE. Central nervous system effects of current and emerging multiple sclerosis-directed immuno-therapies (2008). Clin. Neurol. Neurosurg. 110, 951-957.