RESEARCH FOCUS: How do microglia support myelin health across the lifespan?

RESEARCH FOCUS: How do microglia support myelin health across the lifespan?

How do microglia support developmental myelination in health and injury?

•Investigating roles of microglia in myelin development and homeostasis

•Identifying roles of microglia in hypomyelination following perinatal brain injury

•Identifying biomarkers for risk stratefication and regenerative therapeutic strategies for injured infants

How do microglia drive myelin regeneration?

•Uncovering mechanisms regulating regenerative microglia activation supportive of remyelination

•Identifying regenerative molecules secreted by microglia which promote remyelination

•Revealing crosstalk of microglia with additional immune cells (e.g. monocytes, astrocytes) and elucidating their complementary regenerative functions in remyelination

How do microglia support myelin health in ageing?

•Investigating how white matter microglia change with ageing

•Elucidating the contribution of microglia to loss of myelin integrity with ageing

•Uncovering the consequences of dysfunction of aged white matter microglia on neural function